Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

678
The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
678
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

1.4K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.4K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

16.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
16.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.4K
Overview
85.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a lambda Red based system for gene deletion in Chlamydia.

PloS one·2024
Same author

Chlamydia trachomatis Seroassays Used in Epidemiologic Research: A Narrative Review and Practical Considerations.

The Journal of infectious diseases·2024
Same author

Antibodies from chlamydia-infected individuals facilitate phagocytosis via Fc receptors.

Infection and immunity·2024
Same author

Genomic Analysis of MSM Rectal Chlamydia trachomatis Isolates Identifies Predicted Tissue-Tropic Lineages Generated by Intraspecies Lateral Gene Transfer-Mediated Evolution.

Infection and immunity·2022
Same author

Inter-species lateral gene transfer focused on the Chlamydia plasticity zone identifies loci associated with immediate cytotoxicity and inclusion stability.

Molecular microbiology·2021
Same author

Wikidata as a knowledge graph for the life sciences.

eLife·2020

Related Experiment Video

Updated: Mar 7, 2026

Using Fluorescent Proteins to Visualize and Quantitate Chlamydia Vacuole Growth Dynamics in Living Cells
07:42

Using Fluorescent Proteins to Visualize and Quantitate Chlamydia Vacuole Growth Dynamics in Living Cells

Published on: October 13, 2015

8.0K

Chlamydia trachomatis Cellular Exit Alters Interactions with Host Dendritic Cells.

Ashley M Sherrid1, Kevin Hybiske2

  • 1Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

Infection and Immunity
|February 23, 2017
PubMed
Summary

Chlamydia trachomatis exit via extrusion, forming membrane-bound compartments, triggers rapid dendritic cell apoptosis. This contrasts with lysis, impacting immune response and bacterial survival.

Keywords:
Chlamydiaapoptosisdendritic cellextrusion

More Related Videos

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
07:40

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens

Published on: October 25, 2019

6.5K
Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

13.3K

Related Experiment Videos

Last Updated: Mar 7, 2026

Using Fluorescent Proteins to Visualize and Quantitate Chlamydia Vacuole Growth Dynamics in Living Cells
07:42

Using Fluorescent Proteins to Visualize and Quantitate Chlamydia Vacuole Growth Dynamics in Living Cells

Published on: October 13, 2015

8.0K
Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
07:40

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens

Published on: October 25, 2019

6.5K
Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

13.3K

Area of Science:

  • Pathogenesis
  • Cell Biology
  • Immunology

Background:

  • Pathogen exit strategies are crucial for infection but poorly understood.
  • Chlamydia trachomatis uses lysis or extrusion to exit host cells.
  • Extrusion creates a unique host-membrane-bound bacterial compartment.

Purpose of the Study:

  • To investigate the impact of Chlamydia trachomatis extrusion on host dendritic cell interactions.
  • To compare the effects of extrusion-contained vs. free extracellular bacteria.

Main Methods:

  • Assessed Chlamydia-dendritic cell interactions following bacterial exit via extrusion.
  • Compared host cell response to engulfed extrusions versus free Chlamydia.

Main Results:

  • Engulfment of Chlamydia-containing extrusions induced rapid dendritic cell apoptosis.
  • Uptake of free Chlamydia did not cause apoptosis.
  • Extrusion containment prolonged bacterial survival and altered innate immune signaling.

Conclusions:

  • Chlamydia trachomatis exit via extrusion significantly alters host-pathogen interactions.
  • Extrusion impacts dendritic cell apoptosis, bacterial survival, and immune signaling.