Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
T Cell Types and Functions01:24

T Cell Types and Functions

3.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.0K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.4K
Overview
85.4K
Antigen Processing Pathways01:31

Antigen Processing Pathways

2.7K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
2.7K
Tissue Transplantation01:24

Tissue Transplantation

1.1K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathology of mosquito-borne haemorrhagic fever in the Calcutta outbreak.

Bulletin of the World Health Organization·2010
Same author

Role of reactive oxygen species in renal damage in experimental leprosy.

Leprosy review·1995
Same author

Antiparkinsonian action of dextromethorphan in the reserpine-treated mouse.

European journal of pharmacology·1995
Same author

Duodenal ulcer. Calcium status in isolated parietal cells.

Digestive diseases and sciences·1995
Same author

The Univent tube for airway management in combined ascending and descending thoracic aortic surgery.

Journal of cardiothoracic and vascular anesthesia·1995
Same author

Implementing professional profiling.

British journal of nursing (Mark Allen Publishing)·1995

Related Experiment Video

Updated: Mar 7, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

15.2K

Histocompatiibhity Antigens in Psoriasis.

Tilak R Bedi, S Sengupta, S Sehgal

    Indian Journal of Dermatology, Venereology and Leprology
    |February 23, 2017
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) BW 17 antigen is significantly associated with psoriasis in Indian populations. This finding may help in understanding the genetic basis of psoriasis and its early onset.

    Area of Science:

    • Immunogenetics
    • Dermatology
    • Human Leukocyte Antigen (HLA)

    Background:

    • Psoriasis is a chronic inflammatory skin condition with a complex genetic component.
    • Human Leukocyte Antigen (HLA) genes are known to play a role in immune responses and have been implicated in various autoimmune diseases.

    Purpose of the Study:

    • To investigate the association between specific HLA antigens and psoriasis in an Indian population.
    • To explore the correlation between HLA antigen profiles and clinical characteristics, such as age of onset and psoriatic arthritis.

    Main Methods:

    • HLA typing was performed on 30 Indian patients with psoriasis and 60 healthy controls.
    • Statistical analysis was used to determine significant associations between HLA antigens and the disease.

    More Related Videos

    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
    06:34

    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

    Published on: August 8, 2025

    636
    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
    02:28

    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

    Published on: March 1, 2024

    973

    Related Experiment Videos

    Last Updated: Mar 7, 2026

    Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
    10:31

    Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

    Published on: April 8, 2016

    15.2K
    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
    06:34

    SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments

    Published on: August 8, 2025

    636
    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
    02:28

    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

    Published on: March 1, 2024

    973

    Main Results:

    • The HLA-BW17 antigen was found to be significantly associated with psoriasis in the studied population.
    • A combination of HLA-A1 and HLA-BW17 was observed more frequently in patients (26.6%) compared to controls (5%).
    • Patients with HLA-BW17 and the HLA-A1+BW17 combination exhibited a younger age of onset for psoriasis.

    Conclusions:

    • HLA-BW17 is a potential genetic marker for psoriasis in the Indian population.
    • The presence of HLA-BW17 and its combination with HLA-A1 may be linked to an earlier onset of the disease.
    • HLA-B27 did not show a significant correlation with the presence or absence of psoriatic arthritis in this cohort.