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Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

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Allergic Contact Dermatitis Due To Parthenium Hysterophorus.

V D Tiwari, A S Sohi, T R Chopra

Indian Journal of Dermatology, Venereology and Leprology

|February 23, 2017

Summary

This summary is machine-generated.

Parthenium hysterophorus causes allergic contact dermatitis in fifty patients. Studies identified four dermatitis patterns and immunologically active plant compounds, including the allergen parthenin.

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Area of Science:

Dermatology
Allergology
Plant Chemistry

Background:

Parthenium hysterophorus is a significant cause of allergic contact dermatitis.
Understanding its clinical and epidemiological features is crucial for diagnosis and management.
Identifying active allergenic compounds can aid in developing targeted treatments.

Purpose of the Study:

To detail the clinico-epidemiological features of allergic contact dermatitis caused by Parthenium hysterophorus.
To identify immunologically active fractions from Parthenium hysterophorus extracts.
To investigate the chemical nature of parthenin and explore potential cross-sensitivities.

Main Methods:

Detailed clinical and epidemiological study of 50 patients with suspected Parthenium hysterophorus allergy.
Patch testing with 12 plant extracts in six different solvents.
Limited chemical analysis of plant extracts to isolate active fractions.

Main Results:

Fifty cases of allergic contact dermatitis were analyzed, presenting in atopic, photosensitivity, seborrhoeic, and miscellaneous patterns.
Patch testing revealed differential reactions to various plant extracts.
Chemical analysis identified three immunologically active fractions, with further study on the known allergen parthenin.

Conclusions:

Parthenium hysterophorus is a potent allergen responsible for diverse patterns of allergic contact dermatitis.
Specific plant extracts and fractions demonstrate immunological activity, highlighting key allergenic components.
Further research into parthenin and potential cross-reactivity is warranted for comprehensive patient care.