Lichen Planus Like Lesions Caused by Thiacetazone

Area of Science:

• Dermatology
• Pharmacology
• Infectious Diseases

Background:

• Thiacetazone is a first-line antitubercular medication used in many countries.
• Adverse skin reactions are known side effects of thiacetazone therapy, affecting approximately 10% of patients.

Observation:

• Two cases of patients developing lichen planus-like lesions are presented.
• One patient had a history of hypertrophic lichen planus, while the other had no prior history of the condition.

Findings:

• The observed lichen planus-like lesions are presumed to be a side effect of thiacetazone treatment.
• This suggests a potential link between thiacetazone use and the development of specific dermatological reactions.

Implications:

• Clinicians should be aware of the potential for thiacetazone to induce lichen planus-like eruptions.
• Further investigation may be warranted to understand the mechanism of thiacetazone-induced dermatoses and identify risk factors.