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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Secondary Lymphoid Organs01:15

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Lymph-node Involvement in Tuberculoid Leprosy.

R V Koranne, Ratan Singh, B Iyengar

    Indian Journal of Dermatology, Venereology and Leprology
    |February 23, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Histopathological analysis revealed significant lymph node involvement in 54% of tuberculoid leprosy patients. Acid-fast bacilli and granulomas were detected in lymph nodes, indicating systemic spread of leprosy.

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    Isolation of Murine Lymph Node Stromal Cells
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    Area of Science:

    • Dermatology
    • Infectious Diseases
    • Pathology

    Background:

    • Leprosy is a chronic infectious disease primarily affecting the skin and peripheral nerves.
    • Lymph node involvement in leprosy is not fully understood, particularly in untreated tuberculoid leprosy.

    Purpose of the Study:

    • To histopathologically investigate lymph node involvement in untreated tuberculoid leprosy patients.
    • To determine the presence of Mycobacterium leprae (acid-fast bacilli) and granulomatous inflammation in lymph nodes.

    Main Methods:

    • Histopathological examination of lymph node biopsies from 22 untreated tuberculoid leprosy patients.
    • Comparison with lymph node biopsies from 5 healthy individuals (control group).

    Main Results:

    • 54% of leprosy patients showed lymph node involvement.
    • Granulomas were found in 45.45% of cases, and acid-fast bacilli in 36.36%.
    • Leprous pathology was observed in lymph nodes outside the typical lymphatic drainage area in two cases.

    Conclusions:

    • Lymph node involvement is common in untreated tuberculoid leprosy.
    • Histopathology can detect Mycobacterium leprae and granulomatous inflammation in affected lymph nodes.
    • Leprosy may disseminate to lymph nodes beyond direct cutaneous lesion drainage.