Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resistant Hypertension Variants Link to Hyperaldosteronism and Potassium Levels.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

[Congenital insensitivity to pain caused by a novel SCN9A-genotype].

Laeknabladid·2026
Same author

Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy.

Nature communications·2026
Same author

Genomic analyses implicate hormonal and metabolic dysregulation in polycystic ovary syndrome.

Nature genetics·2026
Same author

A frameshift variant in <i>PKP2</i> can be associated with a complex phenotype in sudden cardiac death: a case report.

European heart journal. Case reports·2026
Same author

Development and validation of a neural network survival prediction model for ischemic heart disease.

Cardiovascular diabetology·2026

Related Experiment Video

Updated: Mar 7, 2026

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation
10:09

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation

Published on: October 14, 2022

4.6K

Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.

Gyda Bjornsdottir1, Stefania Benonisdottir1, Gardar Sveinbjornsson1

  • 1deCODE Genetics/Amgen, Inc., Reykjavik IS-101, Iceland.

Nature Communications
|February 23, 2017
PubMed
Summary

A genome-wide study identified a genetic marker, rs6651255[C], strongly associated with lumbar disc herniation surgery (LDHsurg). This finding may indicate a genetic susceptibility to severe sciatica in patients with lumbar disc herniation.

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.5K

Related Experiment Videos

Last Updated: Mar 7, 2026

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation
10:09

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation

Published on: October 14, 2022

4.6K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.5K

Area of Science:

  • Genetics
  • Orthopedics
  • Epidemiology

Background:

  • Lumbar disc herniation (LDH) is a prevalent condition causing significant disability.
  • Microdiscectomy (LDHsurg) is a surgical intervention for severe LDH cases presenting with sciatica.

Purpose of the Study:

  • To identify genetic factors associated with lumbar disc herniation surgery (LDHsurg).
  • To investigate the relationship between a specific genetic marker and LDH severity.

Main Methods:

  • Genome-wide association study (GWAS) involving 4,748 LDHsurg cases and 282,590 controls.
  • Analysis of genetic markers, including rs6651255[C], and their association with LDHsurg.
  • Mendelian randomization analysis to assess the role of height in the association.

Main Results:

  • Discovery of 37 markers associated with LDHsurg at 8q24.21, notably rs6651255[C] (OR=0.81; P=5.6 × 10-12).
  • rs6651255[C] showed a stronger effect in younger patients.
  • The association of rs6651255[C] with LDHsurg exceeded its effect on height, suggesting a direct role.

Conclusions:

  • rs6651255[C] is a significant genetic risk factor for LDHsurg.
  • The genetic marker may influence susceptibility to severe sciatica in LDH patients.
  • Further research is warranted to elucidate the precise mechanism of rs6651255[C] in LDH pathogenesis.