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Assessment of liver iron overload by 3 T MRI

A Paisant1,2, A Boulic1, E Bardou-Jacquet2,3,4

  • 1Digestive Unit, Department of Radiology, Hôpital Pontchaillou, Rennes University Hospital, 2 rue H. Le Guilloux, 35033, Rennes, France.

Abdominal Radiology (New York)
|February 23, 2017
PubMed
Abstract

Insights

The signal intensity ratio method effectively quantifies liver iron overload at 3 Tesla MRI. This non-invasive technique shows excellent correlation with liver biopsy, offering a reliable tool for diagnosing iron overload.

Area of Science:

  • Radiology
  • Medical Imaging
  • Hepatology

Background:

  • Liver iron overload is a condition requiring accurate quantification for effective management.
  • Magnetic Resonance Imaging (MRI) offers a non-invasive approach to assess liver iron concentration.
  • The signal intensity ratio (SIR) method is a potential MRI technique for quantifying liver iron.

Purpose of the Study:

  • To evaluate the performance and limitations of the SIR method for quantifying liver iron overload at 3 Tesla (3T) MRI.
  • To establish the accuracy of the SIR method compared to liver biopsy.
  • To determine the optimal parameters for SIR-based liver iron quantification at 3T.

Main Methods:

  • Prospective study including 105 patients undergoing liver biopsy and 3T MRI.
  • Liver biopsy provided biochemical assessment of hepatic iron concentration (HIC).
  • 3T MRI utilized single-echo gradient-echo sequences; SIR calculated using an adapted algorithm with halved echo times.

Main Results:

  • 100 patients were analyzed, with HIC ranging from 0-630 µmol/g.
  • Excellent linear correlation (R=0.96, p<0.0001) between biochemical HIC and MR-derived HIC.
  • High sensitivity (83%) and specificity (96%) for detecting iron overload at a threshold of 36 µmol/g.

Conclusions:

  • The SIR method is a reliable and accurate tool for quantifying liver iron overload at 3T MRI.
  • Adapting the echo times by dividing by 2 improves the performance of the SIR method at 3T.
  • This non-invasive method provides a valuable alternative to liver biopsy for assessing hepatic iron concentration.
Keywords:
3 TeslaIron overloadLiverMRIQuantification

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