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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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Curcumin attenuates surgery-induced cognitive dysfunction in aged mice.

Xiang Wu1,2,3, Huixin Chen4, Chunhui Huang5

  • 1Anaesthesia Department of the Affiliated Hospital of Medical College, Ningbo University, Ningbo, 315211, China. wx7322@sina.com.

Metabolic Brain Disease
|February 23, 2017
PubMed
Summary

Curcumin, a compound from turmeric, may prevent post-operative cognitive dysfunction (POCD) in older adults. This study showed curcumin improved memory and brain function in aged mice after surgery.

Keywords:
Anti-oxidant enzymeBDNFChATCurcuminPost-operative cognitive dysfunction

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Gerontology

Background:

  • Post-operative cognitive dysfunction (POCD) is a significant concern in elderly surgical patients.
  • Current pharmacological treatments for POCD remain limited, highlighting the need for novel therapeutic strategies.

Purpose of the Study:

  • To investigate the potential of curcumin, a natural compound from Curcuma longa, in ameliorating post-operative cognitive dysfunction in aged mice.
  • To elucidate the underlying mechanisms of curcumin's effects on cognitive function, including its impact on oxidative stress, neurotrophic signaling, and cholinergic pathways.

Main Methods:

  • Aged mice underwent abdominal surgery to induce cognitive impairment.
  • Curcumin treatment was administered post-surgery.
  • Cognitive function was assessed using behavioral tests.
  • Brain tissue analysis included evaluation of antioxidant enzyme activity, brain-derived neurotrophic factor (BDNF) expression, pAkt levels, and choline acetyltransferase (ChAT) expression.

Main Results:

  • Curcumin significantly ameliorated cognitive deficits in aged mice following abdominal surgery.
  • Curcumin prevented surgery-induced decreases in antioxidant enzyme activity.
  • Curcumin increased the brain-derived neurotrophic factor (BDNF)-positive area and pAkt expression, indicating activation of BDNF signaling.
  • Curcumin neutralized surgery-induced cholinergic dysfunction by affecting choline acetyltransferase expression.

Conclusions:

  • Curcumin demonstrates potential as a prophylactic and therapeutic agent for post-operative cognitive dysfunction.
  • Curcumin's beneficial effects appear to be mediated through multiple mechanisms, including antioxidant activity, enhanced BDNF signaling, and modulation of cholinergic function.