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Circulating endothelial cells, circulating endothelial progenitor cells, and von Willebrand factor in pregnancies

Agata Szpera-Goździewicz1, Maciej Majcherek2, Maciej Boruczkowski2

  • 1Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|February 23, 2017
PubMed

Insights

Circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs) along with von Willebrand factor (vWf) levels vary in pregnant women with hypertensive disorders. These biomarkers differ based on the specific type of hypertension.

Area of Science:

  • Obstetrics and Gynecology
  • Cardiovascular Research
  • Hematology

Background:

  • Hypertensive disorders in pregnancy are significant health concerns.
  • Endothelial dysfunction plays a crucial role in these conditions.
  • Biomarkers of endothelial injury and repair are important for diagnosis and management.

Purpose of the Study:

  • To investigate alterations in circulating endothelial cells (CECs) and circulating endothelial progenitor cells (CEPCs).
  • To measure von Willebrand factor (vWf) plasma concentration in pregnant women with hypertensive disorders.
  • To determine if these markers differ based on the type of hypertensive disorder.

Main Methods:

  • Seventy-five pregnant women were studied.
  • Multicolor flow cytometry was used for CEC and CEPC analysis.
  • Commercial human VWF ELISA kit measured vWf plasma concentration.

Main Results:

  • The highest CEC count was observed in the chronic hypertension group.
  • The highest CEPC count was found in the healthy control group, with the lowest in chronic hypertension.
  • vWf plasma concentration was highest in the pre-eclampsia group; the CEPC/CEC ratio was lowest in chronic hypertension.

Conclusions:

  • The levels of CECs, CEPCs, and vWf are dependent on the specific type of hypertension during pregnancy.
  • These findings suggest distinct endothelial responses to different hypertensive disorders.
  • Biomarker profiles may help differentiate between hypertensive conditions in pregnancy.
Abstract

Keywords:
endotheliumhypertensionmulticolor flow cytometrypre-eclampsiapregnancy

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