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Updated: Mar 7, 2026

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
Published on: November 8, 2014
The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment
Alan Alper Sag1, Oguzhan Sal2, Yagmur Kilic2
1Division of Interventional Radiology, Department of Radiology, Koç University School of Medicine, Istanbul, Turkey.
Abstract:
This review aims to introduce the novel concept of embryological target mining applied to interorgan crosstalk network genesis, and applies embryological target mining to multidrug-resistant essential hypertension (a prototype, complex, undertreated, multiorgan systemic syndrome) to uncover new treatment targets and critique why existing strategies fail. Briefly, interorgan crosstalk pathways represent the next frontier for target mining in molecular medicine. This is because stereotyped stepwise organogenesis presents a unique opportunity to infer interorgan crosstalk pathways that may be crucial to discovering novel treatment targets. Insights gained from this review will be applied to patient management in a clinician-directed fashion.

