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Carborane-layered double hydroxide nanohybrids for potential targeted- and magnetically targeted-BNCT applications
Ahmet Nedim Ay1, Hande Akar1, Adnana Zaulet2
1Department of Chemistry, Hacettepe University, Beytepe Campus, 06800 Ankara, Turkey. ay@hacettepe.edu.tr.
Abstract:
Carborane-intercalated layered double hydroxide nanohybrids (CB-LDH) and a magnesium ferrite (MF) supported-CB-LDH core-shell nanocomposite (CB-LDH@MF) are reported. The preparation of nanohybrids were carried out by exchanging the interlayer nitrate groups of Mg-Al-NO3-LDH with monothiol-o-carborane (SCB), 1-methyl-2-carboxyl-o-carborane (MeCB), 1-phenyl-2-carboxyl-o-carborane (PhCB) and 1,12-dicarboxyl-p-carborane (COOHCB) molecules. A magnetic core-shell nanocomposite was further prepared by supporting the COOHCB-LDH nanohybrid on MF nanoparticles. The obtained materials were characterized by means of several physical and chemical methods. Chemical compositions were determined by elemental analysis, ICP measurements and SEM-EDX data. Structural characterization was performed with powder-XRD, FTIR and magnetization measurements. Morphological analyses were conducted with electron microscopy imaging (SEM and TEM). Thermal stabilities were investigated by TGA/DTA. Carborane release from LDH layers was tested by tracing the amount of boron species transferred to the solution phase with ICP-MS measurements. The results verified that the prepared nanohybrids have the potential to be used in Boron Neutron Capture Therapy (BNCT) and magnetically targeted-BNCT applications.
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