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Updated: Mar 7, 2026

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Outer Retinal Tubulation: A Case Series
Leticia A Rousso1, Julie A Rodman, Brad Sutton
1*OD †OD, MS, FAAO ‡OD, FAAO Nova Southeastern University College of Optometry, Ft. Lauderdale, Florida (LAR, JAR, BS, DLS); and Indianapolis Eye Care Center, Indianapolis, Indiana (BS).
Outer retinal tubulations (ORTs) are newly identified retinal structures. These ovoid spaces appear in various eye conditions, not just macular degeneration, requiring careful diagnosis.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Optical Coherence Tomography
Background:
- Spectral domain optical coherence tomography (SD-OCT) provides enhanced visualization of retinal layers.
- SD-OCT has facilitated the identification of novel retinal pathologies, such as outer retinal tubulations (ORTs).
Observation:
- Outer retinal tubulations (ORTs) are characterized as ovoid hyporeflective spaces within the outer retina.
- The pathogenesis is hypothesized to involve sublethal photoreceptor injury and subsequent reorganization.
- ORTs present with a hyperreflective border surrounding a central lumen.
Findings:
- This study presents diverse clinical cases of ORTs.
- Cases include wet age-related macular degeneration, presumed ocular histoplasmosis syndrome, central areolar choroidal dystrophy, and pathological myopia.
Implications:
- Accurate differentiation of ORTs from other retinal findings is crucial to avoid unnecessary interventions.
- Further understanding of ORTs associated with various retinal disorders may elucidate their formation mechanisms.
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