Related Experiment Video
Updated: Mar 7, 2026

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
Superficial siderosis of the central nervous system is a rare and possibly underdiagnosed disorder
Yara Dadalti Fragoso1, Tarso Adoni2, Joseph Bruno Bidin Brooks1
1Universidade Metropolitana de Santos, Departamento de Neurologia, Santos SP, Brasil.
Methods:
Series of cases collected from Brazilian centers.
Results:
We studied 13 cases of patients presenting with progressive histories of neurological dysfunction caused by SS-CNS. The most frequent clinical findings in these patients were progressive gait ataxia, hearing loss, hyperreflexia and cognitive dysfunction. The diagnoses of SS-CNS were made seven months to 30 years after the disease onset.
Conclusion:
SS-CNS is a rare disease that may remain undiagnosed for long periods. Awareness of this condition is essential for the clinician.
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