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Published on: March 1, 2024
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Impaired Pulmonary Function in Patients with Psoriasis
Didem Didar Balci1, Ebru Celik, Sebahat Genc
1Department of Dermatology, Izmir Tepecik Training and Research Hospital, Izmir, Turkey.
Dermatology (Basel, Switzerland)
|February 23, 2017
Summary
Psoriasis patients exhibit reduced lung function, specifically lower forced expiratory volume in the 1st second/forced vital capacity (FEV1/FVC) ratios and forced expiratory flow at 25-75% of FVC (FEF25-75%). These spirometric findings are independently linked to the presence of psoriasis.
Area of Science:
- Pulmonary Medicine
- Dermatology
- Clinical Research
Background:
- Psoriasis is a chronic inflammatory condition with known associations to other systemic diseases, including chronic obstructive pulmonary disease (COPD).
- Limited research exists on pulmonary function specifically within the psoriasis patient population.
Purpose of the Study:
- To investigate and compare spirometric pulmonary function test parameters between individuals diagnosed with psoriasis and healthy control subjects.
- To determine if specific spirometric measures are independently associated with the presence of psoriasis.
Main Methods:
- A cohort of 96 patients with psoriasis and 60 sex- and age-matched controls underwent spirometric pulmonary function testing.
- Key parameters assessed included percent forced vital capacity (FVC%), percent forced expiratory volume in the 1st second (FEV1%), forced expiratory flow at 25-75% of FVC (FEF25-75%), and the FEV1/FVC ratio.
Main Results:
- Psoriasis patients demonstrated significantly lower mean FEV1/FVC ratios (82.4 ± 6.3 vs. 90.7 ± 10.7, p < 0.001) and FEF25-75% (86.7 ± 24.2 vs. 94.8 ± 23.0, p = 0.04) compared to controls.
- Both the FEV1/FVC ratio and FEF25-75% showed a significant independent association with the presence of psoriasis (p < 0.001 and p = 0.029, respectively).
Conclusions:
- Individuals with psoriasis exhibit impaired lung function, characterized by reduced FEV1/FVC ratios and FEF25-75% when compared to non-psoriatic controls.
- These spirometric abnormalities, specifically FEV1/FVC and FEF25-75%, are significant independent predictors of psoriasis.
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