RAGE polymorphisms and oxidative stress levels in Hashimoto's thyroiditis

Area of Science:

• Genetics and Immunology
• Endocrinology

Background:

• Receptor for advanced glycation end products (RAGE) gene polymorphisms are implicated in autoimmune disorders.
• Oxidative stress is elevated in patients with Hashimoto's thyroiditis.
• The role of RAGE polymorphisms in Hashimoto's thyroiditis and oxidative stress levels remained uninvestigated.

Purpose of the Study:

• To investigate the association between RAGE gene polymorphisms (-429T>C and -374T>A) and Hashimoto's thyroiditis.
• To assess oxidative stress levels in patients with Hashimoto's thyroiditis.

Main Methods:

• Genomic DNA was analyzed for RAGE polymorphisms (-429T>C and -374T>A) in 300 euthyroid women.
• Participants were categorized into three groups: Hashimoto's thyroiditis with treatment, Hashimoto's thyroiditis without treatment, and controls.
• Serum total lipid peroxide levels were measured to evaluate oxidative stress.

Main Results:

• A significant association was found between the RAGE -429T>C polymorphism and Hashimoto's thyroiditis.
• Oxidative stress levels were significantly higher in treated Hashimoto's thyroiditis patients.
• An oxidative stress level of 590 μmol/L was associated with an increased risk of Hashimoto's thyroiditis progression, further elevated in carriers of the RAGE -429T>C polymorphism.

Conclusions:

• The RAGE -429T>C polymorphism and elevated oxidative stress may contribute to Hashimoto's thyroiditis occurrence.
• These factors represent a fraction of the complex pathophysiology of Hashimoto's thyroiditis.