Emergence of Ad-Mediated Combination Therapy Against Cancer: What to Expect?
1Department of Bioengineering, College of Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, 133- 791, Seoul, Korea.
Abstract:
Novel treatment modalities are rapidly advancing toward clinical use as many malignant cancers still remain incurable. Adenovirus (Ad) in particular has been extensively researched as a promising alternative to conventional cancer therapy in the past decades. Although Ad has demonstrated promising therapeutic outcome and cancer specificity in preclinical models, its therapeutic efficacy in clinical trials is still insufficient due to several drawbacks such as rapid clearance of viral particles by host immune response, induction of acute inflammatory response, and hepatotoxicity. In this regard, combination of Ad with other cancer treatment modalities, such as chemotherapy, radiotherapy, or immunotherapy, can be an effective strategy to overcome the limitations of Ad. Cancerspecific and effective expression of multifunctional therapeutic genes by Ad can enhance the therapeutic profile of other treatment modalities, making it a logical candidate for combination therapy to combat malignant tumors.
Insights
Adenovirus (Ad) shows promise for cancer therapy but faces immune clearance and toxicity issues. Combining Ad with chemotherapy, radiotherapy, or immunotherapy can overcome these limitations for improved malignant tumor treatment.
Area of Science:
- Oncolytic virotherapy
- Gene therapy
- Cancer treatment modalities
Background:
- Adenovirus (Ad) is a researched viral vector for cancer therapy.
- Preclinical studies show Ad's potential for cancer specificity and therapeutic outcomes.
- Clinical efficacy of Ad is limited by rapid clearance, inflammation, and hepatotoxicity.
Purpose of the Study:
- To explore combination strategies for Adenovirus (Ad) cancer therapy.
- To overcome the limitations of Ad monotherapy in clinical settings.
- To enhance the therapeutic profile of Ad through combination treatments.
Main Methods:
- Review of Adenovirus (Ad) as a cancer therapeutic agent.
- Analysis of Ad limitations in clinical trials.
- Investigation of combination therapy approaches with Ad.
Main Results:
- Adenovirus (Ad) exhibits promising preclinical cancer-specific outcomes.
- Clinical application of Ad is hindered by immune responses and toxicity.
- Combination therapy with Ad can enhance overall therapeutic efficacy.
Conclusions:
- Adenovirus (Ad) holds potential for cancer treatment, especially in combination therapies.
- Combining Ad with chemotherapy, radiotherapy, or immunotherapy can mitigate its limitations.
- Ad-mediated gene expression can improve the effectiveness of other cancer treatments.
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