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Shoshin beriberi-thiamine responsive pulmonary hypertension in exclusively breastfed infants: A study from northern

Javeed Iqbal Bhat1, Hilal Ahmad Rather2, Ambreen Ali Ahangar3

  • 1Department of Pediatrics, SKIMS Srinagar, J&K, India.

Indian Heart Journal
|February 24, 2017
PubMed

Insights

Thiamine administration effectively resolved pulmonary hypertension in exclusively breastfed infants with Shoshin beriberi. This intervention rapidly reversed high pulmonary pressures and metabolic complications, offering a promising treatment.

Area of Science:

  • Pediatrics
  • Cardiology
  • Nutritional Science

Background:

  • Shoshin beriberi, a severe form of thiamine deficiency, can present with critical cardiovascular complications.
  • Pulmonary hypertension is a significant and potentially fatal complication in infants with Shoshin beriberi.

Purpose of the Study:

  • To investigate the efficacy of thiamine administration in resolving pulmonary hypertension in exclusively breastfed infants diagnosed with Shoshin beriberi.

Main Methods:

  • A prospective cohort study was conducted in a tertiary care hospital.
  • Twenty-nine exclusively breastfed infants with Shoshin beriberi and pulmonary hypertension received intravenous thiamine (100mg/kg stat, then 10mg/day).
  • Outcomes assessed included resolution of shock, metabolic complications, and pulmonary hypertension via echocardiography.

Main Results:

  • All infants presented with pulmonary hypertension and acute metabolic acidosis.
  • Following thiamine administration, repeat echocardiography demonstrated complete resolution of pulmonary hypertension.
  • Four deaths occurred, but the primary cardiovascular complication showed prompt reversal.

Conclusions:

  • Infants with Shoshin beriberi can exhibit severe pulmonary hypertension that is responsive to thiamine.
  • Thiamine challenge provides rapid resolution of metabolic derangements and reverses pulmonary hypertension.
  • This study highlights the critical role of thiamine in managing Shoshin beriberi-associated cardiovascular compromise.
Abstract

Keywords:
BeriberiPulmonary hypertensionThiamine

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