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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9
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Calorically restricted diets decrease PCSK9 in overweight adolescents.

A E Levenson1, C E Milliren2, S B Biddinger1

  • 1Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|February 24, 2017
PubMed
Summary
This summary is machine-generated.

Intensive nutrition therapy significantly lowered proprotein convertase subtilisin kexin type 9 (PCSK9) in overweight youth. This reduction was linked to improved insulin sensitivity, not just weight loss.

Keywords:
AdolescentsDyslipidemiaNutritional TherapyObesityPCSK9

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Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Cardiovascular Disease Risk Factors

Background:

  • Nutritional therapy is primary for childhood hyperlipidemia.
  • Proprotein convertase subtilisin kexin type 9 (PCSK9) regulates cholesterol and is a pharmacotherapy target.
  • Investigating PCSK9 response to nutritional intervention in at-risk youth.

Purpose of the Study:

  • To assess the impact of an intensive nutritional intervention on PCSK9 levels in overweight adolescents with cardiovascular disease (CVD) risk factors.

Main Methods:

  • Twenty-seven overweight/obese adolescents with CVD risk factors participated.
  • Intervention included an 8-week intensive phase (low-fat or low-glycemic load diet, home-delivered meals, weekly counseling) followed by a 4-month maintenance phase.
  • Measurements included anthropometrics, labs, and serum PCSK9 at baseline, 8 weeks, and 6 months.

Main Results:

  • Serum PCSK9 levels decreased by 16.5% at 8 weeks (p < 0.001).
  • PCSK9 levels reverted to baseline by 6 months post-intervention.
  • PCSK9 changes correlated with changes in fasting insulin and HOMA-IR, independent of weight loss.

Conclusions:

  • Intensive dietary intervention effectively reduced PCSK9 levels in adolescents.
  • The association between PCSK9 changes and HOMA-IR suggests a link with insulin sensitivity.
  • Findings highlight the role of diet in modulating PCSK9 beyond weight management in youth.