Related Experiment Video
Updated: Mar 7, 2026

Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
The Potential Use of Pharmacological Agents to Modulate Orthodontic Tooth Movement (OTM)
Thaleia Kouskoura1, Christos Katsaros1, Stephan von Gunten2
1Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern Bern, Switzerland.
Abstract:
The biological processes that come into play during orthodontic tooth movement (OTM) have been shown to be influenced by a variety of pharmacological agents. The effects of such agents are of particular relevance to the clinician as the rate of tooth movement can be accelerated or reduced as a result. This review aims to provide an overview of recent insights into drug-mediated effects and the potential use of drugs to influence the rate of tooth movement during orthodontic treatment. The limitations of current experimental models and the need for well-designed clinical and pre-clinical studies are also discussed.
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