Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

16.1K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
16.1K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

42.6K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
42.6K
Tubular Reabsorption and Secretion01:28

Tubular Reabsorption and Secretion

7.6K
Tubular secretion and reabsorption are two critical processes in the nephron tubule of the kidneys. When the fluid filtered from the glomerulus enters the proximal convoluted tubule, it is referred to as filtrate, and its composition changes due to tubular reabsorption and secretion.
Tubular reabsorption is a selective process that starts when the filtrate enters the proximal tubules. It involves substances traveling through the transcellular route (through the tubule cell and peritubular...
7.6K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

4.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
4.0K
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

15.7K
Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
15.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modified langendorff-free method for isolating cardiomyocytes and non-cardiomyocytes from adult mice.

BMC biotechnology·2026
Same author

Heavy-metal and nutrient enrichment triggered a regime shift in marsh diatom assemblages over the past millennium.

Journal of environmental management·2026
Same author

Mediating effect of sex hormones and modification of lifestyle: Association between pyrethroid exposure and hypertension.

Ecotoxicology and environmental safety·2026
Same author

Multicenter Evaluation of an Edge-to-Edge Repair System in High-Risk Patients With Degenerative Mitral Regurgitation.

Structural heart : the journal of the Heart Team·2026
Same author

Development and validation of a machine learning model for predicting 6-month mortality in patients with infective endocarditis.

Biomedical engineering online·2026
Same author

A novel laparoscopic renal denervation system in a preclinical swine model.

Scientific reports·2026

Related Experiment Video

Updated: Mar 7, 2026

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
07:44

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging

Published on: July 28, 2020

5.4K

Tubular organ epithelialisation.

Rhea Saksena1, Chuanyu Gao1, Mathew Wicox1

  • 1Division of Surgery and Interventional Science, University College London, London, UK.

Journal of Tissue Engineering
|February 24, 2017
PubMed
Summary
This summary is machine-generated.

Tissue engineering aims to repair hollow organs using synthetic scaffolds and stem cells. Successful epithelialization of these artificial organs is crucial for function and requires careful selection of cell sources and scaffold properties.

Keywords:
Tubular scaffoldsbiofunctionalisationepithelialisationhollow organs

More Related Videos

Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

5.8K
Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
06:32

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

598

Related Experiment Videos

Last Updated: Mar 7, 2026

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
07:44

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging

Published on: July 28, 2020

5.4K
Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

5.8K
Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
06:32

Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions

Published on: June 13, 2025

598

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Gastroenterology & Urology

Background:

  • Hollow, tubular organs (e.g., esophagus, trachea, bladder) often require repair or replacement due to disease, representing an unmet clinical need.
  • Current treatments are limited, driving research into tissue engineering for synthetic organ constructs.
  • Epithelial cell integration and functionality within artificial organs remain a significant challenge for successful graft outcomes.

Purpose of the Study:

  • To review tissue engineering strategies for creating epithelialized grafts for hollow organs.
  • To highlight the importance of cell-scaffold interactions and physicochemical properties for successful epithelialization.
  • To consolidate findings from studies on esophageal, tracheal, stomach, intestinal, bladder, and urethral tissue-engineered constructs.

Main Methods:

  • Comprehensive review of existing literature on tissue engineering for hollow organs.
  • Analysis of studies focusing on scaffold materials and cell sourcing for epithelialization.
  • Evaluation of factors influencing cell-scaffold interactions and graft functionality.

Main Results:

  • Smart, functionalized synthetic materials serve as effective scaffolds for organ tissue engineering.
  • Stem cells can be used to repopulate scaffolds, but epithelial cell integration is critical for graft success.
  • Successful epithelialization is contingent upon the chosen cell source and scaffold's physicochemical properties.

Conclusions:

  • Optimizing cell-scaffold interactions is key to overcoming limitations in current tissue-engineered hollow organ grafts.
  • Further research into cell sourcing and scaffold design is necessary to achieve functional epithelialized grafts.
  • Tissue engineering holds promise for addressing the unmet clinical need for hollow organ repair and replacement.