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Updated: Aug 14, 2026

Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
Published on: August 31, 2016
Nonmetastatic gestational trophoblastic neoplasia. Controversies in definition and management
1Yale Center for Trophoblastic Disease, Department of Gynecology and Obstetrics, Yale University School of Medicine, New Haven, Connecticut.
Abstract:
The difficulties with the current definition of nonmetastatic gestational trophoblastic neoplasia are discussed in relation to the evaluation of length of time, amount of human chorionic gonadotropin elevation and histologic criteria used to make the diagnosis. Evaluation of the patient is described, and the effect of more-sophisticated methods of investigation on staging and on therapy is placed in perspective. More-effective, less-toxic and more-efficient chemotherapy delivery systems are available today.
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