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Updated: Mar 7, 2026
Fiber-optic Implantation for Chronic Optogenetic Stimulation of Brain Tissue
Published on: October 29, 2012
Quantitative cognitive-test characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic
I V Fedotov1,2,3, O I Ivashkina3,4, M S Pochechuev3,4
1Physics Department, International Laser Center, M. V. Lomonosov Moscow State University, Moscow, 119992, Russia.
Abstract:
Cognitive tests on representative groups of freely behaving transgenic mice are shown to enable a quantitative characterization of reconnectable implantable fiber-optic neurointerfaces for optogenetic neurostimulation. A systematic analysis of such tests provides a robust quantitative measure for the cognitive effects induced by fiber-optic neurostimulation, validating the performance of fiber-optic neurointerfaces for long-term optogenetic brain stimulations and showing no statistically significant artifacts in the behavior of transgenic mice due to interface implantation.
