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In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene
1Department of Pharmacology, Stanford University School of Medicine, California 94305.
Molecular and Cellular Biology
|August 1, 1987
Abstract:
We used an in situ exonuclease III protection technique (C. Wu, Nature [London] 309:229, 1984) to analyze protein-DNA interactions at a dioxin-responsive enhancer. Our results imply that the 2,3,7,8-tetrachlorodibenzo-p-dioxin-receptor complex interacts with the dioxin-responsive enhancer to activate transcription of the cytochrome P1-450 gene.