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Bone-specific poly(ethylene sodium phosphate)-bearing biodegradable nanoparticles

Yuya Hirano1, Yasuhiko Iwasaki2

  • 1Graduate School of Science and Engineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka, 564-8680, Japan.

Colloids and Surfaces. B, Biointerfaces
|February 24, 2017
PubMed
Summary

Researchers developed novel cholesteryl-functionalized poly(ethylene sodium phosphate) nanoparticles (PEPn·Na NPs) for enhanced bone-targeted drug delivery. These biocompatible nanoparticles show high affinity for bone, improving chemotherapy for osteoporosis and osseous metastases.

Keywords:
Biodegradable polymerBone therapyDrug delivery systemNanoparticlePolyphosphoesterRing-opening polymerization

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