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Neuropathy and IgM paraproteinemia: differential binding of IgM M-proteins to peripheral nerve glycolipids
S Kusunoki1, T Kohriyama, A R Pachner
1Department of Neurology, Yale University School of Medicine, New Haven, CT 06510.
Neurology
|November 1, 1987
Abstract:
Two patients with neuropathy and IgM paraproteinemia displayed different immunoreactivity to acidic peripheral nerve glycolipids. In one patient, immunostaining on thin-layer chromatographic plate revealed binding of the IgM to sulfated glucuronosyl paragloboside (SGPG) and sulfated glucuronosyl lactosaminyl paragloboside (SGLPG). The other IgM bound SGPG, SGLPG, and a new third glycolipid. Immunoreactivity of the IgM varies in this syndrome.