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The Tehran Cardiometabolic Genetic Study (TCGS) created a genome-wide database from over 17,000 participants in the Tehran Lipid and Glucose Study (TLGS). This resource will help identify genetic factors influencing cardiometabolic diseases.

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Area of Science:

  • Genetics
  • Cardiology
  • Endocrinology

Background:

  • Cardiometabolic risk factors, including cardiovascular diseases and diabetes, require multidisciplinary evaluation.
  • The Tehran Lipid and Glucose Study (TLGS) has a long-standing cohort for studying these risk factors.

Purpose of the Study:

  • To establish a comprehensive genome-wide genetic database for at least 16,000 participants of the TLGS.
  • To facilitate research into the genetic underpinnings of cardiometabolic diseases in the Tehran population.

Main Methods:

  • The Tehran Cardiometabolic Genetic Study (TCGS) was developed in partnership with the Research Institute for Endocrine Sciences and deCODE genetics.
  • Genotyping was performed on 17,186 participants using HumanOmniExpress-24-v1-0 bead chips, covering 649,932 single-nucleotide polymorphism loci.
  • The study leverages a 20-year follow-up of participants for major cardiometabolic events.

Main Results:

  • The TCGS cohort includes 17,186 individuals (86.3% of TLGS participants) with available DNA and plasma samples.
  • Genotyping data was successfully obtained for 13,400 individuals (5977 males, 7422 females) with a genotyping rate of 0.9854.
  • The dataset comprises 849 individuals and 3109 families with genotype information.

Conclusions:

  • The TCGS provides a valuable resource for identifying genetic polymorphisms associated with cardiometabolic risk factors in Tehran.
  • Linking genome-wide data with extensive TLGS clinical and behavioral data enables the study of gene-gene and gene-environment interactions.
  • This integrated approach will advance understanding of the genetic basis of cardiometabolic diseases.