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Related Experiment Video

Updated: Mar 7, 2026

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

The microbiome and systemic lupus erythematosus.

Nurit Katz-Agranov¹, Gisele Zandman-Goddard^2,3

¹Department of Internal Medicine, The University of Texas Houston, Health Science Center, Houston, TX, USA.

Immunologic Research

|February 25, 2017

Summary

The gut microbiome influences autoimmune diseases like lupus. Research suggests altered gut microbes correlate with systemic lupus erythematosus (SLE) and may offer new therapeutic targets.

Keywords:

Dysbiosis Gut Lupus Microbiota SLE

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Last Updated: Mar 7, 2026

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Published on: May 2, 2022

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Published on: October 15, 2019

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice

Published on: November 1, 2015

Area of Science:

Microbiome research
Immunology
Autoimmune diseases

Background:

The human gut microbiota plays a crucial role in health and disease.
Alterations in the gut microbiome are linked to various autoimmune conditions.
Emerging evidence suggests a connection between gut microbial composition and lupus.

Purpose of the Study:

To explore the role of gut microbes in the development and manifestations of Systemic Lupus Erythematosus (SLE).
To investigate potential therapeutic strategies targeting the gut microbiome for lupus treatment.

Main Methods:

Review of recent studies on gut microbiome composition and SLE.
Analysis of the potential impact of symbiotic and pathogenic microbes in SLE pathogenesis.

Main Results:

Gut microbial alterations are correlated with SLE disease activity.
The precise roles of specific gut microbes in SLE require further investigation.

Conclusions:

Understanding the gut microbiome's role in SLE can lead to improved biomarkers.
Modulating the gut microbiome through diet, antibiotics, or probiotics may offer novel therapeutic avenues for lupus.