Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.1K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.1K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

11.0K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
11.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Next generation open access visualization of neuroanatomy through 3D modeling and 3D printing.

Anatomical sciences education·2026
Same author

Post-LASIK corneas show sub-clinical differences in sensory nerves and immune cell morphodynamics.

The ocular surface·2026
Same author

Infant Abusive Head Trauma Induces Seizures and Cellular Stress in a Pre-Clinical Mouse Model.

Journal of neurotrauma·2026
Same author

Infection control in the brain and the eye.

Acta ophthalmologica·2026
Same author

Therapeutic targeting of oligodendrocytes in an agent-based model of multiple sclerosis.

PLoS computational biology·2026
Same author

Altered Corneal T-Cell Motility and Sensory Nerve Features in Older Adults With Human Immunodeficiency Virus Infection.

Investigative ophthalmology & visual science·2025

Related Experiment Video

Updated: Mar 7, 2026

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
09:58

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

5.6K

Macrophage physiology in the eye.

Holly R Chinnery1, Paul G McMenamin2, Samantha J Dando2

  • 1Department of Optometry and Vision Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia. holly.chinnery@unimelb.edu.au.

Pflugers Archiv : European Journal of Physiology
|February 25, 2017
PubMed
Summary
This summary is machine-generated.

Ocular macrophages are immune cells found throughout the eye, playing key roles in normal eye function and disease. This review details their distribution, characteristics, and functions in various eye conditions.

Keywords:
CorneaEyeMacrophageMicrogliaRetinaUvea

More Related Videos

Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay
07:19

Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay

Published on: October 18, 2016

10.2K
Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells
10:02

Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells

Published on: December 12, 2014

13.0K

Related Experiment Videos

Last Updated: Mar 7, 2026

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes
09:58

Digestion of Whole Mouse Eyes for Multi-Parameter Flow Cytometric Analysis of Mononuclear Phagocytes

Published on: June 17, 2020

5.6K
Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay
07:19

Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay

Published on: October 18, 2016

10.2K
Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells
10:02

Large-Scale Purification of Porcine or Bovine Photoreceptor Outer Segments for Phagocytosis Assays on Retinal Pigment Epithelial Cells

Published on: December 12, 2014

13.0K

Area of Science:

  • Ophthalmology
  • Immunology
  • Cell Biology

Background:

  • The eye comprises diverse tissues, including transparent structures for light transmission and pigmented tissues for light absorption.
  • Macrophages, a type of immune cell, are ubiquitously distributed across all ocular tissues, from the anterior cornea to the posterior choroid/sclera.

Purpose of the Study:

  • To review the current knowledge on the distribution, phenotype, and physiological functions of macrophages within the eye.
  • To summarize evidence regarding the role of ocular macrophages in pathological conditions.

Main Methods:

  • Literature review of existing studies on ocular macrophages.
  • Analysis of research on macrophage distribution and phenotype in ocular tissues.
  • Synthesis of data on the physiological and pathological roles of these cells.

Main Results:

  • Macrophages exhibit distinct distributions and phenotypes depending on their location within the eye.
  • These cells are involved in maintaining ocular homeostasis and responding to injury or infection.
  • Evidence suggests significant involvement of ocular macrophages in various eye diseases.

Conclusions:

  • Ocular macrophages are critical cellular components with diverse roles throughout the eye.
  • Understanding their function is essential for developing new therapeutic strategies for ocular diseases.