Related Experiment Video

Updated: Mar 7, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

12.6K

Primary and secondary prevention of cardiovascular disease in patients with hyperlipoproteinemia (a)

P Grützmacher1, B Öhm2, S Szymczak2

  • 12nd Medical Clinic - Nephrology, Hypertension and Vascular Diseases, AGAPLESION Markus-Hospital, Frankfurt/Main, Germany. peter.gruetzmacher@fdk.info.

Clinical Research in Cardiology Supplements
|February 25, 2017
PubMed

Insights

Lipoprotein (a) screening identifies high cardiovascular disease risk. While current treatments are limited, lipoprotein (a) apheresis offers a secondary prevention option for progressive cardiovascular disease.

Area of Science:

  • Cardiology
  • Lipidology
  • Preventive Medicine

Background:

  • Elevated Lipoprotein (a) [Lp(a)] is a significant risk factor for cardiovascular disease (CVD).
  • Early detection of asymptomatic atherosclerotic disease is crucial for timely intervention.
  • Current medical treatments for managing high Lp(a) and associated CVD risk remain suboptimal.

Purpose of the Study:

  • To highlight the importance of general Lipoprotein (a) screening for identifying at-risk individuals.
  • To discuss the role of non-invasive methods in detecting early-stage atherosclerotic disease.
  • To evaluate current and potential therapeutic strategies for managing hyperlipoproteinemia (a).

Main Methods:

  • Review of current screening protocols for Lipoprotein (a).
  • Assessment of non-invasive diagnostic techniques for incipient atherosclerotic disease.
  • Analysis of established and emerging treatment modalities, including apheresis and pharmacotherapy.

Main Results:

  • General Lipoprotein (a) screening effectively identifies patients at elevated risk for cardiovascular events.
  • Non-invasive methods enable early detection of subclinical atherosclerosis.
  • Lipoprotein (a) apheresis is an established secondary prevention strategy in specific regions (e.g., Germany).

Conclusions:

  • Routine Lipoprotein (a) screening should be considered for comprehensive cardiovascular risk assessment.
  • Statin therapy and antiplatelet agents form the cornerstone of current medical management.
  • Target levels for LDL-cholesterol may require adjustment in patients with hyperlipoproteinemia (a).

Keywords:
Cardiovascular preventionLipoprotein (a)Lp (a) apheresisTarget LDL cholesterol

More Related Videos

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

15.2K
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.8K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
538
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.6K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
786
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
2.4K
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
722
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
538