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Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase

Haruko Shima1,2, Nobutaka Kiyokawa3, Masashi Miharu3

  • 1Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

Pediatric Blood & Cancer
|February 25, 2017
PubMed

Keywords:
cMplchronic myeloid leukemiaflow cytometry

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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