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[Resistance rates and phenotypic characterization of Streptococcus pyogenes in a paediatric population in Northern

L Calle-Miguel1, C Pérez-Méndez, M D Miguel-Martínez

  • 1Laura Calle-Miguel, Servicio de Pediatría, Hospital de Cabueñes 6ª planta Impar, C/ Los Prados, 395, CP 33394 Gijón, Asturias, Spain. lcallemiguel@gmail.com.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|February 25, 2017
PubMed

Insights

Pediatric Streptococcus pyogenes resistance to erythromycin and clindamycin significantly decreased from 2005-2015 in Northern Spain. Erythromycin resistance phenotypes also shifted, indicating evolving antimicrobial resistance patterns in this common childhood pathogen.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Antimicrobial Resistance

Background:

  • Streptococcus pyogenes is a leading cause of bacterial infections in children.
  • Understanding antimicrobial resistance trends is crucial for effective treatment strategies.

Purpose of the Study:

  • To analyze resistance rates and phenotypes of S. pyogenes isolates in a pediatric population in Northern Spain over an 11-year period.
  • To identify changes in resistance patterns to key antibiotics.

Main Methods:

  • A descriptive retrospective study of 1,794 S. pyogenes isolates from pediatric patients (2005-2015).
  • Comparison of resistance rates and erythromycin resistance phenotypes between two time periods (2005-2009 and 2010-2015).

Main Results:

  • Resistance rates to tetracycline, erythromycin, and clindamycin significantly decreased between the two study periods.
  • A notable reduction in erythromycin-resistant isolates exhibiting the MLSB phenotype was observed.

Conclusions:

  • A significant decrease in S. pyogenes resistance to erythromycin and clindamycin was observed.
  • Changes in erythromycin resistance phenotypes suggest evolving resistance mechanisms in pediatric isolates.
Abstract

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