Flexible Antibacterial Film Based on Conjugated Polyelectrolyte/Silver Nanocomposites

In this work, we report a flexible film based on conjugated polyelectrolyte/silver nanocomposites with efficient antibacterial activity. A flexible poly(dimethylsiloxane) film served as a substrate for deposition of nanostructured silver. A light-activated antibacterial agent, based on the cationic conjugated polyelectrolyte poly({9,9-bis[6'-(N,N-trimethylamino)hexyl]-2,7-fluorenyleneethynylene}-alt-co-1,4-(2,5-dimethoxy)phenylene)dibromide (PFEMO) was self-assembled on the negatively charged substrate. By changing the thickness of the poly(l-lysine)/poly(acrylic acid) multilayers between the metal substrate and PFEMO, we obtained concomitant enhancement of PFEMO fluorescence, phosphorescence, and reactive oxygen species generation. These enhancements were induced by surface plasmon resonance effects of the Ag nanoparticles, which overlapped the PFEMO absorption band. Owing to the combination of enhanced bactericidal effects and good flexibility, these films have great potential for use as novel biomaterials for preventing bacterial infections.