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Published on: March 1, 2022
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Structural bowel damage in quiescent Crohn's disease
Marianne M Amitai1, Moran Zarchin2, Adi Lahat2
1Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.
Summary
Structural bowel damage in quiescent Crohn's disease remains stable over 14 months. This study assessed progression of structural bowel damage (SBD) using the Lemann index (LI) in patients with Crohn's disease.
Area of Science:
- Gastroenterology
- Inflammatory Bowel Disease Research
- Medical Imaging in IBD
Background:
- Crohn's disease (CD) can cause progressive structural bowel damage (SBD), leading to complications.
- Data on SBD progression in CD is limited.
- The Lemann index (LI) is a novel tool integrating clinical, endoscopic, and imaging data to assess SBD.
Purpose of the Study:
- To evaluate the progression of structural bowel damage (SBD) in patients with quiescent Crohn's disease (CD).
Main Methods:
- Prospective study of quiescent CD patients (CDAI<220 for ≥3 months).
- Repeated magnetic resonance enterography (MRE) and video capsule endoscopy (VCE) were performed.
- Structural bowel damage (SBD) assessed using the Lemann index (LI); progression defined as LI > 0.3.
Main Results:
- Significant SBD (LI > 4.8) was present in 21.4% of patients at baseline.
- Disease duration and prior CD-related surgery were associated with significant SBD.
- In patients with follow-up MRE (n=41), LI remained stable over a median of 14.8 months, showing negligible change.
Conclusions:
- Structural bowel damage (SBD) in patients with quiescent Crohn's disease (CD) is stable over a median follow-up of 14 months.
- The Lemann index (LI) indicates stability of SBD in this quiescent patient cohort.
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