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Updated: Mar 7, 2026
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Numerical modeling of vessel geometry to measure hemodynamics parameters non-invasively in cerebral arteriovenous
Y Kiran Kumar1, Shashi Bhushan Mehta2, Manjunath Ramachandra2
1Philips Research, Research scholar, Manipal University, India.
Abstract:
Cerebral arteriovenous malformations (CAVM) are congenital lesions that contain a cluster of multiple arteriovenous shunts (NIDUS). Cardiac arrhythmia in CAVM patients causes irregular changes in blood flow and pressure in the NIDUS area. This paper proposes the framework for creating the lumped model of tortuous vessel structure near NIDUS based on radiological images. This lumped model is to analyze flow variations, with various combinations of the transient electrical signals, which simulate similar conditions of cardiac arrhythmia in CAVM patients. This results in flow variation at different nodes of the lumped model. Here we present two AVM patients with evaluation of 150 vessels locations as node points, with an accuracy of 93%, the sensitivity of 95%, and specificity of 94%. The calculated p-value is smaller than the significance level of 0.05.
