Related Experiment Video

Updated: Feb 10, 2026

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

1.1K

Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization

Qihang Sun1, Zhuxian Zhou1, Nasha Qiu1

  • 1Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Zheda Road 38, 310027, Hangzhou, China.

Advanced Materials (Deerfield Beach, Fla.)
|February 25, 2017
PubMed

Insights

Next-generation cancer nanomedicines need rational design to improve drug efficacy. This review introduces stability, surface, and size transitions (3S transitions) to overcome nanomedicine delivery challenges for enhanced cancer therapy.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Current cancer nanomedicines offer limited therapeutic benefits, primarily mitigating side effects rather than enhancing drug efficacy.
  • Rational design is crucial for developing advanced nanomedicines that improve anticancer drug effectiveness.

Purpose of the Study:

  • To analyze the cancer-drug-delivery process and identify critical steps for enhancing therapeutic efficiency.
  • To address the conflicting nanoproperty requirements at different delivery stages, known as the PEG, surface-charge, size, and stability dilemmas.
  • To propose and review strategies for achieving stability, surface, and size transitions (3S transitions) in nanomedicines.

Main Methods:

  • Analysis of the five-step cancer-drug-delivery cascade (CAPIR cascade) for intravenously administered nanomedicines.
  • Identification of opposing nanoproperty requirements at various stages of drug delivery.
  • Comprehensive review of reported strategies to achieve 3S transitions.

Main Results:

  • High efficiency at each step of the CAPIR cascade is essential for overall therapeutic success.
  • Conflicting demands on nanomedicine properties (PEGylation, surface charge, size, stability) present significant design challenges.
  • 3S transitions offer a viable approach to integrate necessary nanoproperties for improved performance.

Conclusions:

  • Overcoming nanomedicine design dilemmas through 3S transitions is key to developing high-performance anticancer therapies.
  • Further research and development are needed to translate these advanced nanomedicines into clinical practice.
  • Future directions focus on designing nanomedicines with dynamic property-switching capabilities for enhanced cancer treatment.
Keywords:
cancer treatmentsmultifunctional materialsnanomedicinenanoproperty integration

More Related Videos

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

9.4K
Basic Caenorhabditis elegans Methods: Synchronization and Observation11:34

Basic Caenorhabditis elegans Methods: Synchronization and Observation

Published on: June 10, 2012

49.5K

Related Concept Videos

Rationalizing Substitutions01:29

Rationalizing Substitutions

Integrals involving non-rational functions are often difficult to evaluate using standard techniques, especially when radicals appear in the integrand. Rationalizing substitution provides a systematic method for simplifying such integrals by converting them into rational forms that are easier to handle.Consider a rod whose linear mass density depends on a constant linear density, a characteristic length, and the distance from the left end of the rod. Determining the total mass requires...
62
Integration of Rational Functions Using Partial Fractions01:29

Integration of Rational Functions Using Partial Fractions

Rational functions are expressions written as the ratio of two polynomials, and their integrals are evaluated by simplifying the integrand into manageable parts. These functions are classified as proper or improper based on the degrees of the numerator and denominator.A rational function is proper when the degree of the numerator is less than the degree of the denominator. In this case, partial fraction decomposition is used to rewrite the function as a sum of simpler rational terms. The...
99
Rational Expressions01:28

Rational Expressions

Rational expressions are algebraic fractions in which both the numerator and the denominator are polynomials. These expressions follow the arithmetic rules of numerical fractions but require extra care due to the presence of variables. A fundamental part of working with rational expressions is identifying values that make the expression undefined, typically those that result in division by zero or undefined radicals.Determining the DomainThe domain of a rational expression includes all real...
409
Asymptotes in Rational Functions01:30

Asymptotes in Rational Functions

A rational function is defined as the quotient of two polynomials:  where Q(x)≠0, These functions often exhibit asymptotes, which are the lines that the graph approaches but never touches. These asymptotes are classified based on how the function behaves near specific values of the input.Vertical asymptotes occur where the denominator is zero, and the numerator is not, causing the function to be undefined. These are found by solving Q(x)=0. For example:  has a vertical...
266
Rational Emotive Behavior Therapy01:24

Rational Emotive Behavior Therapy

Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert...
456
Group Design02:01

Group Design

The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
10.7K