Lessons learned from Systolic Blood Pressure Intervention Trial
Paul K Whelton1, Jing Chen, Marie Krousel-Wood
1aDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine bDepartment of Medicine, Tulane University School of Medicine cResearch Division, Ochsner Health System, New Orleans, Louisiana, USA.
Current Opinion in Cardiology
|February 25, 2017
Summary
Lowering blood pressure (BP) intensively, as suggested by the Systolic Blood Pressure Intervention Trial (SPRINT), offers significant health benefits for adults with hypertension. This approach is cost-effective and supported by growing evidence.
Area of Science:
- Cardiology
- Public Health
- Clinical Trials
Background:
- The optimal blood pressure (BP) target for managing hypertension remains a subject of ongoing debate.
- Current US hypertension management guidelines have been challenged by recent research findings.
Purpose of the Study:
- To review recent literature concerning the optimal blood pressure goal in hypertension treatment.
- To evaluate the evidence supporting intensive BP lowering strategies.
Main Methods:
- Systematic review of recent articles and clinical trial data.
- Analysis of findings from the Systolic Blood Pressure Intervention Trial (SPRINT).
- Examination of pooled analyses from multiple hypertension studies.
Main Results:
- The Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated significant advantages of intensive BP lowering compared to current guidelines.
- Evidence from SPRINT and other trials indicates substantial health benefits from more aggressive BP reduction.
Conclusions:
- Intensive BP lowering is increasingly recognized as a cost-effective method for improving health in adults with hypertension.
- SPRINT provides strong evidence, augmented by other studies, supporting intensive BP targets across diverse patient populations.
- Further implementation trials are needed to assess the feasibility and effectiveness of intensive BP management in routine clinical practice, including resource-limited settings.
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