HORMONAL SUPPLEMENTATION TRIGGERING CHOROIDAL NEOVASCULARIZATION IN HEALTHY YOUNG FEMALES
Rosa Dolz-Marco1, Nuria Doménech2, Teresa Diago3
1Unit of Macula, Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain.
Purpose:
To report three cases of choroidal neovascularization after hormonal treatment for ovarian stimulation during a fertility therapy.
Methods:
A comprehensive ophthalmic examination was performed in all cases including best-corrected visual acuity, color fundus examination, fluorescein angiography, and optical coherence tomography.
Results:
Three females in their thirties developed unilateral acuity vision loss and metamorphopsia. They all were undergoing hormonal supplementation for ovarian stimulation with gonadotropins at the moment of presentation. Intravitreal therapy with ranibizumab was used; all cases showed a significant functional and anatomical improvement.
Discussion:
Hormonal supplementation for fertility therapy is a common procedure that may be associated with the development of choroidal neovascularization in healthy young females. Further studies should be performed to evaluate this association, but both ophthalmologist and gynecologist should be aware of this potential complication.
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