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Galectin-3 as a marker for clinical prognosis and cardiac remodeling in acute heart failure

R I Lala1,2, D Lungeanu3, D Darabantiu4,5

  • 1"Vasile Goldis" West University Arad, Arad, Romania. radu_lala@yahoo.com.

Herz
|February 26, 2017
PubMed

Insights

Galectin-3 is a significant predictor of mortality in patients with acute heart failure (AHF). Elevated galectin-3 levels correlate with left ventricular remodeling and worse survival outcomes in AHF patients.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Heart Failure Management

Background:

  • Galectin-3 is implicated in heart failure (HF) development.
  • Previous research focused on chronic HF, with limited data on acute HF (AHF).
  • Understanding galectin-3's role in AHF is crucial for prognosis.

Purpose of the Study:

  • To validate galectin-3 as a prognostic marker in AHF patients.
  • To explore the relationship between galectin-3 levels and left ventricular (LV) remodeling in AHF.

Main Methods:

  • A cohort of 69 hospitalized AHF patients was followed for 18 months.
  • Galectin-3 and echocardiographic parameters were assessed at baseline and 6 months.
  • Survival analysis and LV remodeling assessments were conducted.

Main Results:

  • High baseline galectin-3 (>16.5 ng/ml) predicted worse 18-month survival (HR 4.66).
  • Increasing galectin-3 levels over 6 months predicted short-term HF re-admission (HR 4.44).
  • Galectin-3 levels correlated with pathological changes in LV relative wall thickness, end-diastolic diameter, and volume.

Conclusions:

  • Galectin-3 serves as a reliable predictor of long-term mortality in AHF.
  • Increasing galectin-3 levels are associated with left ventricular remodeling in AHF.
Abstract

Keywords:
Cardiac remodeling, ventricularGalectin-3 biomarkerHeart failurePrognostic factorSurvival

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