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Osteoporosis: Treat-to-Target

E Michael Lewiecki1

  • 1New Mexico Clinical Research & Osteoporosis Center, 300 Oak St. NE, Albuquerque, NM, 87106, USA. mlewiecki@gmail.com.

Current Osteoporosis Reports
|February 26, 2017
PubMed
Abstract

Insights

Treat-to-target therapy for osteoporosis aims to personalize patient care. Achieving a T-score greater than -2.5 shows promise for reducing fracture risk, but more research is needed.

Area of Science:

  • Osteoporosis management
  • Bone health research
  • Clinical trial analysis

Background:

  • Osteoporosis treatment decisions can be challenging.
  • A treat-to-target approach offers a structured method for managing osteoporosis.
  • Individualized care is crucial for effective osteoporosis management.

Purpose of the Study:

  • To review current evidence on treatment targets for osteoporosis.
  • To explore the clinical applications of a treat-to-target strategy.
  • To guide clinicians in osteoporosis treatment decisions.

Main Methods:

  • Review of randomized placebo-controlled trials.
  • Analysis of bone mineral density (BMD) changes and fracture risk.
  • Evaluation of T-score thresholds for treatment efficacy.

Main Results:

  • Higher bone mineral density increases correlate with reduced fracture risk.
  • T-scores above -2.5 appear to be a key target.
  • Limited additional fracture protection observed with T-scores above -2.0.

Conclusions:

  • The treat-to-target paradigm enhances individualized osteoporosis care.
  • A T-score target greater than -2.5 is the most promising based on current data.
  • Further validation is required to confirm the clinical utility of treat-to-target in osteoporosis.
Keywords:
GoalGoal-directedOsteoporosisTargetTreatment

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