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Cyclopia and congenital cytomegalovirus infection
P J Byrne1, M M Silver, J M Gilbert
1Department of Pediatrics, St. Josephs Hospital, London, Ontario, Canada.
American Journal of Medical Genetics
|September 1, 1987
Abstract:
We describe the first documented association of congenital cytomegalovirus (CMV) infection and cyclopia. A previous report has suggested that any infant with congenital ocular defects should be investigated for CMV infection [Frenkel et al, 1980]. Our case underlines this suggestion and questions a teratogenic role for CMV in cyclopiaholoprosencephaly. More documented cases may help clarify the relationship of transplacental CMV infection to the holoprosencephaly developmental field defect, including cyclopia.