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PI-RADSv2: How we do it.

Matthew D Greer1,2, Peter L Choyke1, Baris Turkbey1

  • 1Molecular Imaging Program, NCI, NIH, Bethesda, Maryland, USA.

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|February 26, 2017
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Summary
This summary is machine-generated.

Prostate cancer screening using prostate-specific antigen (PSA) has limitations. Multiparametric magnetic resonance imaging (mpMRI) with PI-RADSv2 improves detection of clinically significant cancer but requires further standardization for consistent results.

Keywords:
PI-RADSv2mpMRIprostate cancerprostate imaging

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Area of Science:

  • Radiology
  • Urology
  • Oncology

Background:

  • Prostate-specific antigen (PSA) testing for prostate cancer screening faces criticism due to limitations in detecting clinically significant cancer (CSC).
  • Multiparametric magnetic resonance imaging (mpMRI) offers a potential improvement by guiding biopsies to better identify CSC and reduce detection of low-grade disease.
  • mpMRI currently suffers from a lack of standardization and low interobserver agreement, hindering its widespread adoption.

Purpose of the Study:

  • To discuss the clinical and technical considerations for implementing the Prostate Imaging Reporting and Diagnostic System version 2 (PI-RADSv2).
  • To review current research and adaptations related to PI-RADSv2 in prostate mpMRI.
  • To evaluate PI-RADSv2's effectiveness in standardizing prostate mpMRI and improving CSC detection.

Main Methods:

  • Discussion of clinical and technical aspects of PI-RADSv2 implementation.
  • Review of existing research on PI-RADSv2 and prostate mpMRI.
  • Analysis of PI-RADSv2's impact on standardization and reproducibility.

Main Results:

  • PI-RADSv2 represents a significant advancement in standardizing prostate mpMRI protocols.
  • The system aids in increasing the detection of clinically significant prostate cancer.
  • Reader reproducibility and standardization comparable to clinical blood tests remain challenges.

Conclusions:

  • PI-RADSv2 is a crucial step towards standardizing prostate mpMRI for improved cancer detection.
  • Further research and quality assurance initiatives are necessary to enhance mpMRI consistency and reliability.
  • Addressing reader variability is essential for optimizing the clinical utility of PI-RADSv2.