Related Experiment Video
Updated: Mar 7, 2026

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
Published on: July 11, 2025
Self-esteem as an important factor in quality of life and depressive symptoms in anosmia: A pilot study
K Kollndorfer1, J L Reichert2,3, B Brückler2
1Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.
Objectives:
Previous research has reported a negative impact of olfactory dysfunction on quality of life (QoL) and depressive symptoms. As self-esteem was identified as a contributing factor to depression, this study aimed to investigate QoL, depressive symptoms and self-esteem in patients with smell loss.
Design:
Prospective controlled study.
Setting:
Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, in co-operation with the Department of Ear, Nose and Throat Diseases, Medical University of Vienna, Austria.
Participants:
Twenty-two anosmic patients (12 females, 10 males) and 25 healthy controls (15 females, 10 males) participated in this study.
Main Outcome Measures:
Olfactory performance was assessed using the Sniffin' Sticks battery. In addition, psychological questionnaires that covered the topics quality of life (WHOQOL-BREF), depressive symptoms (BDI-II) and self-esteem (MSWS) were conducted.
Results:
The results of this study revealed a decrease in QoL and reduced body-related self-esteem in anosmic patients. Furthermore, QoL and self-esteem were correlated with depressive symptoms.
Conclusion:
As self-esteem, QoL and depressive symptoms in anosmia interact with each other, we suggest that self-esteem should be considered in the medical history, in order to provide a personalised intervention, adapted to the patient's needs.
Related Concept Videos
Benefits of Self-Esteem
Sources of Self-Esteem III: Social Comparison
Self-Discrepancy and Its Effects
Olfactory Receptors: Location and Structure
Need for Self-Esteem
Self-Esteem

