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[The cell infected by cytomegalovirus].
Annales De Medecine Interne
|January 1, 1987
Summary
Human cytomegaloviruses (CMV) have long reproductive cycles and can cause latent infections. While not definitively oncogenic, they may act as cocarcinogens.
Area of Science:
- Virology
- Oncology
- Immunology
Context:
- Human cytomegaloviruses (CMV) belong to the beta-herpesviridae subfamily.
- CMV exhibits a long reproductive cycle and a narrow host range.
- Infection can result in infectious virus production or latent infection.
Purpose:
- To describe the characteristics of cytomegaloviruses.
- To explore the outcomes of cell infection by CMV.
- To discuss the potential oncogenic properties of CMV.
Summary:
- Cytomegaloviruses (CMV) are characterized by prolonged replication cycles, restricted host specificity, and the ability to establish latent infections.
- CMV infection in human fibroblasts, the sole permissive cell type in vitro, leads to either infectious virus production or a latent state.
- This latent infection can be reactivated under conditions of cellular immunodeficiency.
- While CMV shares traits with oncogenic viruses, conclusive evidence linking them to human tumors is absent.
Impact:
- CMV's role as a potential cocarcinogen warrants further investigation.
- Understanding CMV latency and reactivation is crucial for managing immunocompromised individuals.
- Further research is needed to clarify the oncogenic potential of CMV.