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  • 1BET Solutions, 116 Alexandras Av., GR-11472 Athens, Greece.

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Summary

Monte Carlo (MC) simulations using the GATE toolkit enable accurate absorbed dose quantification in medical physics. This review highlights GATE

Keywords:
DosimetryGATEMonte Carlo simulationsRadiotherapy

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Area of Science:

  • Medical Physics
  • Computational Science
  • Radiological Sciences

Background:

  • Monte Carlo (MC) simulations are crucial for understanding physical processes in medical physics.
  • Accurate absorbed dose quantification is essential for preclinical and pediatric studies.
  • GATE is an open-source MC toolkit widely used for medical physics simulations.

Purpose of the Study:

  • To review GATE dosimetry applications in diagnostic and therapeutic simulated protocols.
  • To highlight the need for accurate absorbed dose quantification in specific applications.
  • To present the capabilities of GATE in medical physics dosimetry.

Main Methods:

  • Utilizing the open-source GATE MC toolkit for simulating imaging, radiotherapy, and dosimetry.
  • Assessing deposited energy and absorbed dose per tissue/organ during treatment planning.
  • Describing realistic dosimetric applications including molecular imaging, radio-immunotherapy, radiotherapy, and brachytherapy.

Main Results:

  • GATE has been successfully applied to Dose Point Kernels, S-values, and Brachytherapy parameters.
  • Simulated data from GATE show reliable modeling of particle beams when compared to experimental data.
  • Individualized dosimetry and combined imaging/therapy dose monitoring simulations were reported using computational phantoms.

Conclusions:

  • GATE MC simulations, combined with anthropomorphic models and clinical data, facilitate personalized medical protocols.
  • This review covers diverse GATE dosimetry applications and tools for realistic clinical simulations.
  • Accurate dose assessment in medical physics is achievable with advanced simulation tools like GATE.