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Updated: Mar 7, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents
Jing Yang1, Zhengchao Tu2, Xin Xu1
1College of Pharmaceutical Science, Soochow University, 199 Ren Ai Road, Suzhou 215123, China.
Abstract:
In the present study, endoperoxide and 4-anilinoqnazoline were conjugated to obtain a series of compounds. These conjugates exhibited high antiproliferative potency against a number of cancer cell lines, including the epidermal growth factor receptor (EGFR) L858R/T790M mutant cell. Compound 5 was selected as a representative for mechanistic study. Further experiments revealed the conjugate's reactive oxygen species (ROS) generating ability, apoptosis inducing activity and involvement in EGFR downstream signaling pathways.
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