Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ultrasonography01:17

Ultrasonography

8.2K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Magnetic resonance imaging-guided large-scale lesion patterning with high-intensity focused ultrasound in homogeneous phantoms.

Medical physics·2026
Same author

Impact of Three-dimensional-printed Skull Inserts of Different Thickness on Magnetic Resonance-guided Focused Ultrasound Heating in a Head Phantom.

Journal of medical ultrasound·2026
Same author

Multi-channel flow phantom for MRI-guided focused ultrasound.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

NLMap-ATVR: A novel combination of nonlinear mapping network and adaptive total variation regularization for MRI denoising.

Magnetic resonance imaging·2025
Same author

Low-Complexity Robotic Device for Magnetic Resonance Imaging-Guided Needle Biopsy.

The international journal of medical robotics + computer assisted surgery : MRCAS·2025
Same author

Simple Frame-based Approach for MR Imaging-guided Abdominal Biopsy: Preliminary Evaluation in a Phantom Model.

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine·2025

Related Experiment Video

Updated: Mar 7, 2026

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
07:42

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

Published on: March 13, 2012

18.5K

Microbubble-Based Sonothrombolysis Using a Planar Rectangular Ultrasonic Transducer.

Nicos Papadopoulos1, Christakis Damianou2

  • 1Department of Bioengineering, City University, London, UK.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|February 26, 2017
PubMed
Summary
This summary is machine-generated.

Ultrasound combined with microbubbles significantly enhances tenecteplase-induced thrombolysis for stroke treatment. Lower frequencies and higher microbubble doses improve clot removal efficiency through nonthermal mechanisms.

Keywords:
TNK-tPAintravascularstrokethrombus ultrasound

More Related Videos

Introduction to the Ultrasound Targeted Microbubble Destruction Technique
08:24

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

16.1K
Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
06:29

Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

Published on: February 5, 2022

5.0K

Related Experiment Videos

Last Updated: Mar 7, 2026

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model
07:42

MRI-guided Disruption of the Blood-brain Barrier using Transcranial Focused Ultrasound in a Rat Model

Published on: March 13, 2012

18.5K
Introduction to the Ultrasound Targeted Microbubble Destruction Technique
08:24

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

16.1K
Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
06:29

Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability

Published on: February 5, 2022

5.0K

Area of Science:

  • Biomedical Engineering
  • Acoustic Medicine
  • Thrombolysis Research

Background:

  • Investigating ultrasound's potential to enhance thrombolysis for stroke treatment.
  • Utilizing tenecteplase (TNK-tPA) as the primary thrombolytic agent.

Purpose of the Study:

  • Evaluate small ultrasonic transducers for enhancing TNK-tPA-induced thrombolysis.
  • Assess ultrasound's efficacy with and without microbubbles (MBs) under realistic flow conditions.

Main Methods:

  • In vitro flow model using porcine blood clots.
  • Two ultrasonic transducers (3.7 and 5.2 MHz) with a pulsed protocol (1°C temperature elevation).
  • Measured thrombolysis efficacy by mass clot removed (mg).

Main Results:

  • Thrombolysis efficacy decreased with higher ultrasound frequencies.
  • Combination of 3.7 MHz ultrasound and MBs with TNK-tPA significantly enhanced clot removal.
  • Higher MB doses correlated with increased thrombolytic efficacy.

Conclusions:

  • Lower ultrasound frequencies warrant further investigation for improved thrombolysis.
  • 3.7 MHz ultrasound and MBs offer a potent nonthermal strategy to enhance TNK-tPA efficacy.
  • Microbubble dosage is a critical factor in optimizing ultrasound-assisted thrombolysis.