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Related Concept Videos

Micelles01:30

Micelles

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Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
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Nicotine-based surface active ionic liquids: Synthesis, self-assembly and cytotoxicity studies.

Gurbir Singh1, Raman Kamboj2, Venus Singh Mithu1

  • 1Department of Chemistry, UGC-centre for Advance Studies - II, Guru Nanak Dev University, Amritsar 143005, India.

Journal of Colloid and Interface Science
|February 26, 2017
PubMed
Summary

New nicotine-based surfactants, surface active ionic liquids (SAILs), exhibit enhanced self-assembly in water. These SAILs show lower critical micelle concentrations and potential for biological applications due to non-cytotoxicity.

Keywords:
CytotoxicityNicotineSelf-assemblySurface active ionic liquidsSurfactants

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biophysical Chemistry

Background:

  • Surface active ionic liquids (SAILs) are amphiphilic compounds with unique properties.
  • Nicotine-based SAILs offer a novel platform for self-assembly studies.
  • Understanding micelle formation is crucial for designing functional materials.

Purpose of the Study:

  • To synthesize and characterize novel ester-functionalized nicotine-based SAILs ([CnENic][Br]).
  • To investigate the self-assembly behavior and micellization thermodynamics of these SAILs in aqueous solutions.
  • To explore the potential biological applications of these novel SAILs.

Main Methods:

  • Synthesis and characterization of [CnENic][Br] SAILs.
  • Conductivity measurements to determine critical micelle concentration (cmc) and counterion binding (β).
  • Isothermal titration calorimetry (ITC) for thermodynamic analysis.
  • Spectroscopic techniques (fluorescence, 1H NMR, T1 relaxation, ROESY) for molecular-level insights.
  • Dynamic light scattering (DLS) and transmission electron microscopy (TEM) for micelle morphology.
  • Cytotoxicity assays using C6-Glioma cell line.

Main Results:

  • Synthesized SAILs ([CnENic][Br], n=8, 10, 12) with bromide counterions.
  • SAILs exhibited lower cmc values (2-3 fold) compared to conventional surfactants.
  • Inherent fluorescence provided insights into micellar interactions.
  • Thermodynamic parameters confirmed micellization.
  • NMR and relaxation studies elucidated micelle internal structure.
  • DLS and TEM revealed micelle size and shape.
  • SAILs demonstrated non-cytotoxicity towards C6-Glioma cells.

Conclusions:

  • Ester-functionalized nicotine-based SAILs self-assemble effectively in aqueous media.
  • These SAILs possess favorable properties like low cmc and non-cytotoxicity.
  • The findings suggest potential utility of these novel SAILs in diverse biological applications.