Related Experiment Video
Updated: Mar 7, 2026
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Community-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus in critically-ill patients:
Nuria Carballo1, Marta De Antonio-Cuscó2, Daniel Echeverría-Esnal2
1Servicio de Farmacia, Universitat Autònoma de Barcelona, Hospital del Mar, Barcelona.. NCarballo@parcdesalutmar.cat.
Introduction:
Community-acquired pneumonia (CAP) is associated with high morbidity and mortality rates. Despite methicillin-resistant Staphylococcus aureus (MRSA) having often been associated with nosocomial pneumonia, the condition of some MRSA CAP patients is severe enough to warrant their being admitted to ICU.
Objective:
The purpose of this study is to conduct a systematic review of the literature on antibiotic treatment of MRSA CAP in critically-ill patients.
Material And Methods:
An online search was conducted for locating articles on MRSA CAP in critically ill patients. Relevant publications were identified in PUBMED, the BestPractice database, UpToDate database and the Cochrane Library for articles published in English within the December 2001 - April 2016 time frame.
Results:
A total of 70 articles were found to have been published, 13 (18.8%) having been included and 57 (81.4%) excluded. Cohort studies were predominant, having totaled 16 in number (20.7%) as compared to one sole cross-sectional study (3.5%).
Conclusions:
The experience in the treatment of MRSA CAP in patients requiring admission to ICU is quite limited. Vancomycin or linezolid seem to be the treatments of choice for MRSA CAP, although there not be any specific recommendation in this regard. It may be useful to use alternative routes, such as administration via aerosolized antibiotics, continuous infusion or in association with other antibiotics.
Insights
Treatment of severe methicillin-resistant Staphylococcus aureus community-acquired pneumonia (MRSA CAP) in ICU patients is limited. Vancomycin or linezolid are preferred, with aerosolized or continuous infusion antibiotics as potential alternatives.
Area of Science:
- Critical care medicine
- Infectious diseases
- Pharmacology
Background:
- Community-acquired pneumonia (CAP) presents significant morbidity and mortality.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen associated with severe CAP, often requiring intensive care unit (ICU) admission.
Purpose of the Study:
- To systematically review the literature on antibiotic treatment for MRSA CAP in critically-ill patients.
- To identify current treatment strategies and their limitations.
Main Methods:
- A systematic literature search was performed in databases including PubMed, BestPractice, UpToDate, and Cochrane Library.
- Articles published in English between December 2001 and April 2016 were included.
- Study selection focused on MRSA CAP in critically-ill patients.
Main Results:
- Out of 70 identified articles, 13 were included in the review.
- Cohort studies were the predominant study design (20.7%).
- The majority of identified articles (81.4%) were excluded.
Conclusions:
- Limited clinical experience exists for treating MRSA CAP in ICU patients.
- Vancomycin and linezolid are considered primary treatment options.
- Alternative administration routes like aerosolized antibiotics, continuous infusion, or combination therapy may be beneficial.
More Related Videos
07:46Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
Published on: June 4, 2012
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
Related Concept Videos
01:30Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
01:30Pneumonia III: Complications and Assessment
01:28Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
01:30Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
01:29Pneumonia II: Pathophysiology