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Updated: Mar 7, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Risk factors for visual field progression of normal-tension glaucoma in patients with myopia
Hyoung Won Bae1, Sang Jin Seo1, Sang Yeop Lee1
1Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea.
Objective:
To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia.
Design:
Longitudinal, observational study.
Participants:
Fifty-one eyes of 51 NTG patients with myopia (less than -0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013.
Methods:
Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model.
Results:
The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11-14.92 and 1.27-15.04; p = 0.03 and 0.02, respectively).
Conclusions:
Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.
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