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Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Enhancing Visual Outcomes in Cataract Surgery: A Novel Technique to Prevent Posterior Capsular Opacification Through IOL Rotation

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Published on: July 7, 2023

Phaco-trabectome versus phaco-iStent in patients with open-angle glaucoma.

Khaliq Kurji¹, Christopher J Rudnisky¹, Jaspreet S Rayat¹

¹Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.

Canadian Journal of Ophthalmology. Journal Canadien D'Ophtalmologie

|February 27, 2017

Summary

This summary is machine-generated.

Phaco-trabectome (PT) and phaco-iStent (Pi) both effectively lower intraocular pressure (IOP) in open-angle glaucoma patients. However, phaco-iStent surgery demonstrated a significantly better safety profile with fewer complications.

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Area of Science:

Ophthalmology
Glaucoma Surgery
Minimally Invasive Glaucoma Surgery (MIGS)

Background:

Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
Effective intraocular pressure (IOP) management is crucial for OAG treatment.
Surgical interventions like phaco-trabectome (PT) and phaco-iStent (Pi) are utilized for IOP control.

Purpose of the Study:

To compare the efficacy and safety of phaco-trabectome (PT) versus phaco-iStent (Pi) in managing intraocular pressure (IOP) in patients with open-angle glaucoma (OAG).

Main Methods:

A retrospective comparative case series design was employed.
Data from 70 eyes of 55 OAG patients undergoing either PT or Pi surgery between 2010-2012 were analyzed.
Outcomes included IOP reduction, medication reduction, safety profile, and best-corrected visual acuity at 12 months.

Main Results:

Both PT and Pi groups showed significant IOP reduction at 12 months.
No significant difference was found in relative IOP reduction (PT 24% vs. Pi 22%) or medication use between the groups.
The phaco-iStent (Pi) group experienced significantly fewer postoperative complications (5) compared to the phaco-trabectome (PT) group (20).

Conclusions:

Both phaco-trabectome and phaco-iStent are effective in lowering IOP in OAG patients at 12 months.
Phaco-iStent surgery is associated with a superior safety profile and fewer complications postoperatively.